Molecular mechanisms of “detachment-induced apoptosis—Anoikis”
J Grossmann - Apoptosis, 2002 - Springer
J Grossmann
Apoptosis, 2002•SpringerApoptosis following loss of cell anchorage is of relevance for development, tissue
homeostasis and disease. In the following the role of cell-matrix anchorage as well as cell-
cell anchorage for cell survival and apoptosis is reviewed and the complex molecular
mechanisms inducing and perpetuating detachment-induced apoptosis will be discussed
with special emphasis on the role of caspases, p53, bcl-2 family members and the Fas
signaling pathway.
homeostasis and disease. In the following the role of cell-matrix anchorage as well as cell-
cell anchorage for cell survival and apoptosis is reviewed and the complex molecular
mechanisms inducing and perpetuating detachment-induced apoptosis will be discussed
with special emphasis on the role of caspases, p53, bcl-2 family members and the Fas
signaling pathway.
Abstract
Apoptosis following loss of cell anchorage is of relevance for development, tissue homeostasis and disease. In the following the role of cell-matrix anchorage as well as cell-cell anchorage for cell survival and apoptosis is reviewed and the complex molecular mechanisms inducing and perpetuating detachment-induced apoptosis will be discussed with special emphasis on the role of caspases, p53, bcl-2 family members and the Fas signaling pathway.
Springer