[HTML][HTML] Calcineurin-GATA4 pathway is involved in β-adrenergic agonist-responsive endothelin-1 transcription in cardiac myocytes
T Morimoto, K Hasegawa, H Wada, T Kakita… - Journal of Biological …, 2001 - ASBMB
Increases in the expression of endothelin-1 (ET-1) in cardiac myocytes play a critical role in
the development of heart failure in vivo. Whereas norepinephrine (NE) is a potent inducer of
ET-1 expression in cardiac myocytes, the signaling pathways that link NE to inducible
cardiac ET-1 expression are unknown. Adrenergic stimulation results in an increase in
intracellular calcium levels, which in turn activates calcineurin. Here, we have shown that
stimulation with NE markedly increased the expression of theET-1 gene in primary cardiac …
the development of heart failure in vivo. Whereas norepinephrine (NE) is a potent inducer of
ET-1 expression in cardiac myocytes, the signaling pathways that link NE to inducible
cardiac ET-1 expression are unknown. Adrenergic stimulation results in an increase in
intracellular calcium levels, which in turn activates calcineurin. Here, we have shown that
stimulation with NE markedly increased the expression of theET-1 gene in primary cardiac …