[HTML][HTML] HOXA5-twist interaction alters p53 homeostasis in breast cancer cells
IA Stasinopoulos, Y Mironchik, A Raman… - Journal of Biological …, 2005 - ASBMB
The homeotic gene HOXA5 has been shown to play an important role in breast
tumorigenesis. We have shown that loss of p53 correlated with loss of a developmentally
regulated transcription factor, HOXA5, in primary breast cancer. Searching for potential
protein interacting partners we found that HOXA5 binds to an anti-apoptotic protein, Twist.
Furthermore, Twist-overexpressing MCF-7 cells displayed a deregulated p53 response to γ-
radiation and decreased regulation of downstream target genes. Using a p53-promoter …
tumorigenesis. We have shown that loss of p53 correlated with loss of a developmentally
regulated transcription factor, HOXA5, in primary breast cancer. Searching for potential
protein interacting partners we found that HOXA5 binds to an anti-apoptotic protein, Twist.
Furthermore, Twist-overexpressing MCF-7 cells displayed a deregulated p53 response to γ-
radiation and decreased regulation of downstream target genes. Using a p53-promoter …