[HTML][HTML] Regulation of BRCA1 expression and its relationship to sporadic breast cancer

CR Mueller, CD Roskelley - Breast Cancer Research, 2002 - Springer
CR Mueller, CD Roskelley
Breast Cancer Research, 2002Springer
Germ-line mutations in the BRCA1 tumour suppressor gene contribute to familial breast
tumour formation, but there is no evidence for direct mutation of the BRCA1 gene in the
sporadic form of the disease. In contrast, decreased expression of the BRCA1 gene has
been shown to be common in sporadic tumours, and the magnitude of the decrease
correlates with disease progression. BRCA1 expression is also tightly regulated during
normal breast development. Determining how these developmental regulators of BRCA1 …
Abstract
Germ-line mutations in the BRCA1 tumour suppressor gene contribute to familial breast tumour formation, but there is no evidence for direct mutation of the BRCA1 gene in the sporadic form of the disease. In contrast, decreased expression of the BRCA1 gene has been shown to be common in sporadic tumours, and the magnitude of the decrease correlates with disease progression. BRCA1 expression is also tightly regulated during normal breast development. Determining how these developmental regulators of BRCA1 expression are co-opted during breast tumourigenesis could lead to a better understanding of sporadic breast cancer aetiology and the generation of novel therapeutic strategies aimed at preventing sporadic breast tumour progression.
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