Organization of iron-sulfur clusters in respiratory complex I
P Hinchliffe, LA Sazanov - Science, 2005 - science.org
Science, 2005•science.org
Complex I of respiratory chains plays a central role in bioenergetics and is implicated in
many human neurodegenerative diseases. An understanding of its mechanism requires a
knowledge of the organization of redox centers. The arrangement of iron-sulfur clusters in
the hydrophilic domain of complex I from Thermus thermophilus has been determined with
the use of x-ray crystallography. One binuclear and six tetranuclear clusters are arranged,
maximally 14 angstroms apart, in an 84-angstrom-long electron transfer chain. The …
many human neurodegenerative diseases. An understanding of its mechanism requires a
knowledge of the organization of redox centers. The arrangement of iron-sulfur clusters in
the hydrophilic domain of complex I from Thermus thermophilus has been determined with
the use of x-ray crystallography. One binuclear and six tetranuclear clusters are arranged,
maximally 14 angstroms apart, in an 84-angstrom-long electron transfer chain. The …
Complex I of respiratory chains plays a central role in bioenergetics and is implicated in many human neurodegenerative diseases. An understanding of its mechanism requires a knowledge of the organization of redox centers. The arrangement of iron-sulfur clusters in the hydrophilic domain of complex I from Thermus thermophilus has been determined with the use of x-ray crystallography. One binuclear and six tetranuclear clusters are arranged, maximally 14 angstroms apart, in an 84-angstrom-long electron transfer chain. The binuclear cluster N1a and the tetranuclear cluster N7 are not in this pathway. Cluster N1a may play a role in the prevention of oxidative damage. The structure provides a framework for the interpretation of the large amounts of data accumulated on complex I.
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