[HTML][HTML] A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor γ-activating properties
MJ Reginato, ST Bailey, SL Krakow, C Minami… - Journal of Biological …, 1998 - ASBMB
Thiazolidinediones (TZDs) constitute an exciting new class of antidiabetic compounds,
which function as activating ligands for peroxisome proliferator-activated receptor γ
(PPARγ). Until now, there has been an excellent correlation between in vivo hypoglycemic
potency and in vitro binding and activation of PPARγ by TZDs. We have characterized MCC-
555, a novel thiazolidinedione ligand for PPARγ with unique functional properties. The
antidiabetic potency of this compound is greater than that of other TZDs, including …
which function as activating ligands for peroxisome proliferator-activated receptor γ
(PPARγ). Until now, there has been an excellent correlation between in vivo hypoglycemic
potency and in vitro binding and activation of PPARγ by TZDs. We have characterized MCC-
555, a novel thiazolidinedione ligand for PPARγ with unique functional properties. The
antidiabetic potency of this compound is greater than that of other TZDs, including …