Objective. Cryptococcus neoformans is an important cause of central nervous system
infection in adults with acquired immunodeficiency syndrome (AIDS) but an unusual cause
of disease in children with AIDS. The basis for this age-related difference in incidence is not
known but may be caused by differences in exposure or immune response. The objective of
this study was to determine whether the low prevalence of cryptococcal disease among
children is related to a lack of exposure to C neoformans. Methods. Sera were obtained from …