Role of genetic background in P selectin-dependent immune surveillance of the central nervous system
MD Carrithers, I Visintin, C Viret… - Journal of …, 2002 - Elsevier
Although the blood–brain barrier and blood cerebrospinal fluid barrier maintain the central
nervous system (CNS) as an immunologically privileged site, T lymphocytes can migrate
through unstimulated brain endothelium and epithelium to perform immune surveillance or
initiate inflammation. Our prior results suggested that early CNS migration of a CD4 Th1 cell
line was facilitated by P selectin (CD62P) in (PL/J× SJL/J) F1 mice. Here, quantitative
analysis of migration 2 h following adoptive transfer of fluorescently labeled cells revealed a …
nervous system (CNS) as an immunologically privileged site, T lymphocytes can migrate
through unstimulated brain endothelium and epithelium to perform immune surveillance or
initiate inflammation. Our prior results suggested that early CNS migration of a CD4 Th1 cell
line was facilitated by P selectin (CD62P) in (PL/J× SJL/J) F1 mice. Here, quantitative
analysis of migration 2 h following adoptive transfer of fluorescently labeled cells revealed a …