[HTML][HTML] Pattern recognition receptors: doubling up for the innate immune response
S Gordon - Cell, 2002 - cell.com
S Gordon
Cell, 2002•cell.comAntigen presenting cells (macrophages and dendritic cells) express pattern recognition
molecules that are thought to recognize foreign ligands during early phases of the immune
response. The best known of these are probably the Toll-like receptors, but a number of
other receptors are also involved. Several of these recognize endogenous as well as
exogenous ligands, suggesting that they play a dual role in normal tissue function and host
defense.
molecules that are thought to recognize foreign ligands during early phases of the immune
response. The best known of these are probably the Toll-like receptors, but a number of
other receptors are also involved. Several of these recognize endogenous as well as
exogenous ligands, suggesting that they play a dual role in normal tissue function and host
defense.
Abstract
Antigen presenting cells (macrophages and dendritic cells) express pattern recognition molecules that are thought to recognize foreign ligands during early phases of the immune response. The best known of these are probably the Toll-like receptors, but a number of other receptors are also involved. Several of these recognize endogenous as well as exogenous ligands, suggesting that they play a dual role in normal tissue function and host defense.
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