Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant …
A Sheryanna, G Bhangal, J McDaid… - Journal of the …, 2007 - journals.lww.com
Activation of p38 mitogen-activated protein kinase (MAPK) is known to be important in
cytokine production and cell survival in inflammation. This study examined the effect of
inhibiting p38 MAPK after onset of renal injury in an experimental model of crescentic
glomerulonephritis. Furthermore, this study investigated whether p38 MAPK inhibition would
cause widespread suppression of the cytokine network in vivo or uncontrolled apoptosis. In
the in vivo studies, daily treatment with a p38 MAPKα/β inhibitor was started 1 h (early …
cytokine production and cell survival in inflammation. This study examined the effect of
inhibiting p38 MAPK after onset of renal injury in an experimental model of crescentic
glomerulonephritis. Furthermore, this study investigated whether p38 MAPK inhibition would
cause widespread suppression of the cytokine network in vivo or uncontrolled apoptosis. In
the in vivo studies, daily treatment with a p38 MAPKα/β inhibitor was started 1 h (early …