[HTML][HTML] slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon
CW Schweinfest, DD Spyropoulos… - Journal of Biological …, 2006 - ASBMB
Mutations in the SLC26A3 (DRA (down-regulated in adenoma)) gene constitute the
molecular etiology of congenital chloride-losing diarrhea in humans. To ascertain its role in
intestinal physiology, gene targeting was used to prepare mice lacking slc26a3. slc26a3-
deficient animals displayed postpartum lethality at low penetrance. Surviving dra-deficient
mice exhibited high chloride content diarrhea, volume depletion, and growth retardation. In
addition, the large intestinal loops were distended, with colonic mucosa exhibiting an …
molecular etiology of congenital chloride-losing diarrhea in humans. To ascertain its role in
intestinal physiology, gene targeting was used to prepare mice lacking slc26a3. slc26a3-
deficient animals displayed postpartum lethality at low penetrance. Surviving dra-deficient
mice exhibited high chloride content diarrhea, volume depletion, and growth retardation. In
addition, the large intestinal loops were distended, with colonic mucosa exhibiting an …