[HTML][HTML] CD25+ CD4+ T cells in human cord blood: an immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene
Y Takahata, A Nomura, H Takada, S Ohga… - Experimental …, 2004 - Elsevier
OBJECTIVE: To address the role of cord blood (CB) CD25+ CD4+ T cells, the gene
expressions and function of this subset were analyzed. MATERIALS AND METHODS:
CD25+ CD4+ T cells fractionated from CB of term and preterm infants were subjected to flow
cytometry, quantitative polymerase chain reaction analysis for cytokines, costimulatory
molecules, and transcription factors, and functional assays. RESULTS: Human preterm CB
contained a high proportion of CD25+ CD4+ T cells that declined with gestational age to the …
expressions and function of this subset were analyzed. MATERIALS AND METHODS:
CD25+ CD4+ T cells fractionated from CB of term and preterm infants were subjected to flow
cytometry, quantitative polymerase chain reaction analysis for cytokines, costimulatory
molecules, and transcription factors, and functional assays. RESULTS: Human preterm CB
contained a high proportion of CD25+ CD4+ T cells that declined with gestational age to the …