Fanconi anemia (FA) is a rare hereditary disease characterized by bone marrow failure and
developmental anomalies; a high incidence of myelodysplasia (MDS), acute nonlymphocytic
leukemia (AML), and solid tumors; and cellular hypersensitivity to cross-linking agents. The
genetic basis of FA is mutations in any one of the known FA genes. The function of the
proteins is largely unknown, but many form complexes with each other, and in one canonical
“pathway,” eight of the known FA proteins bind together in a complex and monoubiquitinate …