Induction of granulocyte-macrophage colony-stimulating factor by a new cytokine, ML-1 (IL-17F), via Raf I-MEK-ERK pathway
M Kawaguchi, F Kokubu, M Odaka, S Watanabe… - Journal of Allergy and …, 2004 - Elsevier
BACKGROUND: ML-1 (IL-17F) is a recently discovered cytokine, and its function remains
elusive. GM-CSF is a crucial cytokine for the maturation of various cell types and regulates
allergic airway inflammation. OBJECTIVE: The functional effect of ML-1 in the expression of
GM-CSF was investigated. METHODS: The levels of gene and protein expression in normal
human bronchial epithelial cells (NHBEs) in the presence or absence of various kinase
inhibitors or, in some cases, of a Raf1 dominant-negative mutant were determined by RT …
elusive. GM-CSF is a crucial cytokine for the maturation of various cell types and regulates
allergic airway inflammation. OBJECTIVE: The functional effect of ML-1 in the expression of
GM-CSF was investigated. METHODS: The levels of gene and protein expression in normal
human bronchial epithelial cells (NHBEs) in the presence or absence of various kinase
inhibitors or, in some cases, of a Raf1 dominant-negative mutant were determined by RT …