Histamine intolerance results from a disequilibrium of accumulated histamine and the
capacity for histamine degradation. Histamine is a biogenic amine that occurs to various
degrees in many foods. In healthy persons, dietary histamine can be rapidly detoxified by
amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine
toxicity. Diamine oxidase (DAO) is the main enzyme for the metabolism of ingested
histamine. It has been proposed that DAO, when functioning as a secretory protein, may be …