[HTML][HTML] Male mice that do not express group VIA phospholipase A2 produce spermatozoa with impaired motility and have greatly reduced fertility
S Bao, DJ Miller, Z Ma, M Wohltmann, G Eng… - Journal of Biological …, 2004 - ASBMB
The Group VIA Phospholipase A 2 (iPLA 2 β) is the first recognized cytosolic Ca 2+-
independent PLA 2 and has been proposed to participate in arachidonic acid (20: 4)
incorporation into glycerophosphocholine lipids, cell proliferation, exocytosis, apoptosis, and
other processes. To study iPLA 2 β functions, we disrupted its gene by homologous
recombination to generate mice that do not express iPLA 2 β. Heterozygous iPLA 2 β+/–
breeding pairs yield a Mendelian 1: 2: 1 ratio of iPLA 2 β+/+, iPLA 2 β+/–, and iPLA 2 β …
independent PLA 2 and has been proposed to participate in arachidonic acid (20: 4)
incorporation into glycerophosphocholine lipids, cell proliferation, exocytosis, apoptosis, and
other processes. To study iPLA 2 β functions, we disrupted its gene by homologous
recombination to generate mice that do not express iPLA 2 β. Heterozygous iPLA 2 β+/–
breeding pairs yield a Mendelian 1: 2: 1 ratio of iPLA 2 β+/+, iPLA 2 β+/–, and iPLA 2 β …