[HTML][HTML] Altered lung phospholipid metabolism in mice with targeted deletion of lysosomal-type phospholipase A21
AB Fisher, C Dodia, SI Feinstein, YS Ho - Journal of lipid research, 2005 - ASBMB
Lung surfactant dipalmitoylphosphatidylcholine (DPPC) is endocytosed by alveolar
epithelial cells and degraded by lysosomal-type phospholipase A 2 (aiPLA 2). This enzyme
is identical to peroxiredoxin 6 (Prdx6), a bifunctional protein with PLA 2 and GSH peroxidase
activities. Lung phospholipid was studied in Prdx6 knockout (Prdx6−/−) mice. The
normalized content of total phospholipid, phosphatidylcholine (PC), and disaturated
phosphatidylcholine (DSPC) in bronchoalveolar lavage fluid, lung lamellar bodies, and lung …
epithelial cells and degraded by lysosomal-type phospholipase A 2 (aiPLA 2). This enzyme
is identical to peroxiredoxin 6 (Prdx6), a bifunctional protein with PLA 2 and GSH peroxidase
activities. Lung phospholipid was studied in Prdx6 knockout (Prdx6−/−) mice. The
normalized content of total phospholipid, phosphatidylcholine (PC), and disaturated
phosphatidylcholine (DSPC) in bronchoalveolar lavage fluid, lung lamellar bodies, and lung …