3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, statins, have been shown to
positively impact vascular function independent of their plasma lipid-lowering action.
Several of these beneficial effects involve modulation of gene expression. Here we explored
whether the transcription factor Kruppel-like factor 2 (KLF2), a biomechanically activated
gene we recently identified as part of the endothelial" atheroprotective phenotype," is
regulated by statins and whether this mechanism is important for the non-lipid lowering …