Influence of oxygen radical injury on DNA methylation

S Cerda, SA Weitzman - Mutation Research/Reviews in Mutation Research, 1997 - Elsevier
One of the most prevalent products of oxygen radical injury in DNA is 8-hydroxyguanosine.
Cells must be able to withstand damage by oxygen radicals and possess specific repair
mechanisms that correct this oxidative lesion. However, when these defenses are
oversaturated, such as under conditions of high oxidative stress, or when repair is inefficient,
the miscoding potential of this lesion can result in mutations in the mammalian genome. In
addition to causing genetic changes, active oxygen species can lead to epigenetic …