[CITATION][C] S-Adenosylmethionine; a new intermediate formed enzymatically from L-methionine and adenosinetriphosphate
GL Cantoni - Journal of Biological Chemistry, 1953 - Elsevier
GL Cantoni
Journal of Biological Chemistry, 1953•ElsevierIt is now well established that ATP'plays an essential r&e in the transmethylation reactions
which utilize methionine as the methyl donor (1, 2). Evidence has already been presented
which indicates that the need for ATP is related to the activation of methionine (3) and it has
been suggested that this activation is a prerequisite for the transfer of the methyl group of
suitable methyl acceptors (4). The reaction catalyzed by the methionine-activating enzyme is
described as follows:(1) t-Methionine f ATP GSH-------+ active methionine+ 31P Mg++
which utilize methionine as the methyl donor (1, 2). Evidence has already been presented
which indicates that the need for ATP is related to the activation of methionine (3) and it has
been suggested that this activation is a prerequisite for the transfer of the methyl group of
suitable methyl acceptors (4). The reaction catalyzed by the methionine-activating enzyme is
described as follows:(1) t-Methionine f ATP GSH-------+ active methionine+ 31P Mg++
It is now well established that ATP’plays an essential r&e in the transmethylation reactions which utilize methionine as the methyl donor (1, 2). Evidence has already been presented which indicates that the need for ATP is related to the activation of methionine (3) and it has been suggested that this activation is a prerequisite for the transfer of the methyl group of suitable methyl acceptors (4). The reaction catalyzed by the methionine-activating enzyme is described as follows:(1) t-Methionine f ATP GSH-------+ active methionine+ 31P Mg++
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