PAR-2 agonists activate trigeminal nociceptors and induce functional competence in the delta opioid receptor
AM Patwardhan, A Diogenes, KA Berg… - Pain, 2006 - Elsevier
The role of protease activated receptor-2 (PAR-2) activation in trigeminal nociception and in
induction of functional competence in the delta opioid receptor (DOR) is not known. In this
study, we evaluated whether agonists of PAR-2 activate the capsaicin-sensitive subclass of
trigeminal nociceptors in a PLC–PKC-dependent manner and induce functional competence
in the DOR. Adult male rat trigeminal ganglion (TG) cultured neurons were treated with the
PAR-2 agonist (SL-NH2) or an enzyme activator of PAR (trypsin) and the activation of TG …
induction of functional competence in the delta opioid receptor (DOR) is not known. In this
study, we evaluated whether agonists of PAR-2 activate the capsaicin-sensitive subclass of
trigeminal nociceptors in a PLC–PKC-dependent manner and induce functional competence
in the DOR. Adult male rat trigeminal ganglion (TG) cultured neurons were treated with the
PAR-2 agonist (SL-NH2) or an enzyme activator of PAR (trypsin) and the activation of TG …