[HTML][HTML] Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2
M Murakami, H Naraba, T Tanioka, N Semmyo… - Journal of Biological …, 2000 - ASBMB
Here we report the molecular identification of membrane-bound glutathione (GSH)-
dependent prostaglandin (PG) E 2 synthase (mPGES), a terminal enzyme of the
cyclooxygenase (COX)-2-mediated PGE 2 biosynthetic pathway. The activity of mPGES was
increased markedly in macrophages and osteoblasts following proinflammatory stimuli.
cDNA for mouse and rat mPGESs encoded functional proteins that showed high homology
with the human ortholog (microsomal glutathioneS-transferase-like 1). mPGES expression …
dependent prostaglandin (PG) E 2 synthase (mPGES), a terminal enzyme of the
cyclooxygenase (COX)-2-mediated PGE 2 biosynthetic pathway. The activity of mPGES was
increased markedly in macrophages and osteoblasts following proinflammatory stimuli.
cDNA for mouse and rat mPGESs encoded functional proteins that showed high homology
with the human ortholog (microsomal glutathioneS-transferase-like 1). mPGES expression …