[HTML][HTML] Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A2
M Murakami, S Masuda, S Shimbara, Y Ishikawa… - Journal of Biological …, 2005 - ASBMB
Human group III secreted phospholipase A 2 (sPLA 2-III) consists of a central group III sPLA
2 domain flanked by unique N-and C-terminal domains. We found that the sPLA 2 domain
alone was sufficient for its catalytic activity and for its prostaglandin E 2 (PGE 2)-generating
functions in various cell types. In several if not all cell types, the N-and C-terminal domains of
sPLA 2-III were proteolytically removed, leading to the production of the form containing only
the sPLA 2 domain, which could be further N-glycosylated at two consensus sites …
2 domain flanked by unique N-and C-terminal domains. We found that the sPLA 2 domain
alone was sufficient for its catalytic activity and for its prostaglandin E 2 (PGE 2)-generating
functions in various cell types. In several if not all cell types, the N-and C-terminal domains of
sPLA 2-III were proteolytically removed, leading to the production of the form containing only
the sPLA 2 domain, which could be further N-glycosylated at two consensus sites …