[HTML][HTML] Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII)
M Murakami, S Masuda, S Shimbara, S Bezzine… - Journal of Biological …, 2003 - ASBMB
Here we report cellular arachidonate (AA) release and prostaglandin (PG) production by
novel classes of secretory phospholipase A 2 s (sPLA 2 s), groups III and XII. Human group
III sPLA 2 promoted spontaneous AA release, which was augmented by interleukin-1, in
HEK293 transfectants. The central sPLA 2 domain alone was sufficient for itsin vitro
enzymatic activity and for cellular AA release at the plasma membrane, whereas either the
unique N-or C-terminal domain was required for heparanoid-dependent action on cells to …
novel classes of secretory phospholipase A 2 s (sPLA 2 s), groups III and XII. Human group
III sPLA 2 promoted spontaneous AA release, which was augmented by interleukin-1, in
HEK293 transfectants. The central sPLA 2 domain alone was sufficient for itsin vitro
enzymatic activity and for cellular AA release at the plasma membrane, whereas either the
unique N-or C-terminal domain was required for heparanoid-dependent action on cells to …