IFN-γ mediates crescent formation and cell-mediated immune injury in murine glomerulonephritis
AR Kitching, SR Holdsworth… - Journal of the American …, 1999 - journals.lww.com
Features of crescentic glomerulonephritis suggest that it results from a T helper 1 (Th1)
nephritogenic immune response. Interferon-γ (IFN-γ), produced by Th1 cells, is involved in T
cell-directed macrophage activation in effector Th1 responses. The hypothesis that
endogenous IFN-γ contributes to the development of crescentic glomerulonephritis was
tested by comparing the development of glomerulonephritis (induced by a planted antigen)
and immune responses in normal C57BL/6 mice (IFN-γ+/+) and in mice genetically deficient …
nephritogenic immune response. Interferon-γ (IFN-γ), produced by Th1 cells, is involved in T
cell-directed macrophage activation in effector Th1 responses. The hypothesis that
endogenous IFN-γ contributes to the development of crescentic glomerulonephritis was
tested by comparing the development of glomerulonephritis (induced by a planted antigen)
and immune responses in normal C57BL/6 mice (IFN-γ+/+) and in mice genetically deficient …