Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis
DRW Jayne, G Gaskin, N Rasmussen… - Journal of the …, 2007 - journals.lww.com
Systemic vasculitis associated with autoantibodies to neutrophil cytoplasmic antigens
(ANCA) is the most frequent cause of rapidly progressive glomerulonephritis. Renal failure
at presentation carries an increased risk for ESRD and death despite immunosuppressive
therapy. This study investigated whether the addition of plasma exchange was more
effective than intravenous methylprednisolone in the achievement of renal recovery in those
who presented with a serum creatinine> 500 μmol/L (5.8 mg/dl). A total of 137 patients with a …
(ANCA) is the most frequent cause of rapidly progressive glomerulonephritis. Renal failure
at presentation carries an increased risk for ESRD and death despite immunosuppressive
therapy. This study investigated whether the addition of plasma exchange was more
effective than intravenous methylprednisolone in the achievement of renal recovery in those
who presented with a serum creatinine> 500 μmol/L (5.8 mg/dl). A total of 137 patients with a …