[HTML][HTML] The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway

PP Roux, AL Bhakar, TE Kennedy, PA Barker - Journal of Biological …, 2001 - ASBMB
The Akt kinase plays a crucial role in supporting Trk-dependent cell survival, whereas the
p75 neurotrophin receptor (p75NTR) facilitates cellular apoptosis. The precise mechanism
that p75NTR uses to promote cell death is not certain, but one possibility is that p75NTR-
dependent ceramide accumulation inhibits phosphatidylinositol 3-kinase-mediated Akt
activation. To test this hypothesis, we developed a system for examining p75NTR-
dependent apoptosis and determined the effect of p75NTR on Akt activation. Surprisingly …