[HTML][HTML] Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor
T Harayama, H Shindou, R Ogasawara… - Journal of Biological …, 2008 - ASBMB
Platelet-activating factor (PAF) is a potent lipid mediator playing various inflammatory and
physiological roles. PAF is biosynthesized through two independent pathways called the de
novo and remodeling pathways. Lyso-PAF acetyltransferase (lyso-PAF AT) was believed to
biosynthesize PAF under inflammatory conditions, through the remodeling pathway. The first
isolated lyso-PAF AT (LysoPAFAT/LPCAT2) had consistent properties. However, we show in
this study the finding of a second lyso-PAF AT working under noninflammatory conditions …
physiological roles. PAF is biosynthesized through two independent pathways called the de
novo and remodeling pathways. Lyso-PAF acetyltransferase (lyso-PAF AT) was believed to
biosynthesize PAF under inflammatory conditions, through the remodeling pathway. The first
isolated lyso-PAF AT (LysoPAFAT/LPCAT2) had consistent properties. However, we show in
this study the finding of a second lyso-PAF AT working under noninflammatory conditions …