Treatment with FTY720 during the induction or effector phase suppresses the development of experimental allergic conjunctivitis in mice
T Sumi, A Fukushima, K Nishino, K Fukuda… - Cell Biology …, 2009 - Elsevier
PURPOSE: To investigate whether experimental allergic conjunctivitis (EC) can be
suppressed by treatment with the immunomodulatory drug FTY720, which reduces the
recruitment of effector T cells into inflammatory sites. METHODS: BALB/c mice were actively
immunized with ragweed (RW) and then injected intraperitoneally with FTY720 on days 0, 2,
4, 6 and 8 (induction phase treatment) followed by challenge on day 10 with RW-containing
eye drops. Alternatively, naïve mice that received RW-primed splenocytes were injected …
suppressed by treatment with the immunomodulatory drug FTY720, which reduces the
recruitment of effector T cells into inflammatory sites. METHODS: BALB/c mice were actively
immunized with ragweed (RW) and then injected intraperitoneally with FTY720 on days 0, 2,
4, 6 and 8 (induction phase treatment) followed by challenge on day 10 with RW-containing
eye drops. Alternatively, naïve mice that received RW-primed splenocytes were injected …