[HTML][HTML] RIP2 is a novel NF-κB-activating and cell death-inducing kinase
Through specific interactions with members of the tumor necrosis receptor (TNFR) family,
adapter molecules such as the serine/threonine (Ser/Thr) kinase RIP mediate divergent
signaling pathways including NF-κB activation and cell death. In this study, we have
identified and characterized a novel 61-kDa protein kinase related to RIP that is a
component of both the TNFR-1 and the CD40 signaling complexes. Receptor
interactingprotein-2 (RIP2) contains an N-terminal domain with homology to Ser/Thr kinases …
adapter molecules such as the serine/threonine (Ser/Thr) kinase RIP mediate divergent
signaling pathways including NF-κB activation and cell death. In this study, we have
identified and characterized a novel 61-kDa protein kinase related to RIP that is a
component of both the TNFR-1 and the CD40 signaling complexes. Receptor
interactingprotein-2 (RIP2) contains an N-terminal domain with homology to Ser/Thr kinases …