[HTML][HTML] Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration

BA Yi, O Wernet, KR Chien - The Journal of clinical …, 2010 - Am Soc Clin Investig
BA Yi, O Wernet, KR Chien
The Journal of clinical investigation, 2010Am Soc Clin Investig
The ability to create new functional cardiomyocytes is the holy grail of cardiac regenerative
medicine. From studies using model organisms, new insights into the fundamental pathways
that drive heart muscle regeneration have begun to arise as well as a growing knowledge of
the distinct families of multipotent cardiovascular progenitors that generate diverse lineages
during heart development. In this Review, we highlight this intersection of the
“pregenerative” biology of heart progenitor cells and heart regeneration and discuss the …
The ability to create new functional cardiomyocytes is the holy grail of cardiac regenerative medicine. From studies using model organisms, new insights into the fundamental pathways that drive heart muscle regeneration have begun to arise as well as a growing knowledge of the distinct families of multipotent cardiovascular progenitors that generate diverse lineages during heart development. In this Review, we highlight this intersection of the “pregenerative” biology of heart progenitor cells and heart regeneration and discuss the longer term challenges and opportunities in moving toward a therapeutic goal of regenerative cardiovascular medicine.
The Journal of Clinical Investigation