The role of T/B lymphocyte collaboration in the regulation of autoimmune and alloimmune responses

H Noorchashm, SA Greeley, A Naji - Immunologic research, 2003 - Springer
H Noorchashm, SA Greeley, A Naji
Immunologic research, 2003Springer
The present review highlights the two areas of research pursuit in our laboratory:(1) the
regulation of the autoimmune T cell response to pancreatic islet β cells using the nonobese
diabetic (NOD) mouse model of type 1 diabetes and (2) the regulation the T cell response to
alloantigens. Our work has established a central role for B lymphocytes in driving both
autoimmune and allo-immune T cell responses. Our studies indicate that:(1) B cell-deficient
NOD mice are protected from autoimmune diabetes;(2) targeted disruption of cognate T/B …
Abstract
The present review highlights the two areas of research pursuit in our laboratory: (1) the regulation of the autoimmune T cell response to pancreatic islet β cells using the nonobese diabetic (NOD) mouse model of type 1 diabetes and (2) the regulation the T cell response to alloantigens. Our work has established a central role for B lymphocytes in driving both autoimmune and allo-immune T cell responses. Our studies indicate that: (1) B cell-deficient NOD mice are protected from autoimmune diabetes; (2) targeted disruption of cognate T/B cell collaboration via major histocompatibility complex (MHC) class II prevents both T cell-mediated islet destruction and allograft rejection; and (3) maternal transmission of islet-reactive autoantibodies potentiates the activation of diabetogenic T cells, highlighting the important role of B cells in the early targeting of islet β cells.
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