[HTML][HTML] Peroxisome proliferator-activated receptor δ activation promotes cell survival following hypertonic stress
COX2-selective non-steroidal anti-inflammatory drugs (NSAIDs) cause selective apoptosis
of renal medullary interstitial cells (RMIC) in vivo and reduce their ability to tolerate
hypertonic stress in vitro. To determine the mechanism by which COX2 activity promotes
RMIC viability, we examined the capacity of COX2-derived prostanoids to promote RMIC
survival. Although RMICs synthesize prostaglandin E2 (PGE2)≫ PGI2> PGF2a> TxA2, only
PGI2 enhanced RMIC viability following hypertonic stress. RMICs do not express the …
of renal medullary interstitial cells (RMIC) in vivo and reduce their ability to tolerate
hypertonic stress in vitro. To determine the mechanism by which COX2 activity promotes
RMIC viability, we examined the capacity of COX2-derived prostanoids to promote RMIC
survival. Although RMICs synthesize prostaglandin E2 (PGE2)≫ PGI2> PGF2a> TxA2, only
PGI2 enhanced RMIC viability following hypertonic stress. RMICs do not express the …