Autophagy in Caenorhabditis elegans

T Sigmond, J Barna, ML Tóth, K Takács‐Vellai… - Methods in …, 2008 - Elsevier
Autophagy (cellular self‐eating) is a highly regulated, lysosome‐mediated catabolic process
of eukaryotic cells to segregate by a special membrane and subsequently degrade their own
constituents during development or starvation. Electron microscopy analysis reveals
autophagic elements in various cell types of the nematode Caenorhabditis elegans, whose
genome contains counterparts of several yeast genes involved in autophagy. Genetic
manipulation inactivating autophagy‐related genes in C. elegans causes defects in …