The RAG1 and RAG2 proteins catalyze V (D) J recombination and are essential for
generation of the diverse repertoire of antigen receptor genes and effective immune
responses. RAG2 is composed of a" core" domain that is required for the recombination
reaction and a C-terminal nonessential or" non-core" region. Recent evidence has emerged
arguing that the non-core region plays a critical regulatory role in the recombination
reaction, and mutations in this region have been identified in patients with …