Contribution of TRPV1 to the bradykinin-evoked nociceptive behavior and excitation of cutaneous sensory neurons
K Katanosaka, RK Banik, R Giron, T Higashi… - Neuroscience …, 2008 - Elsevier
Bradykinin (BK), a major inflammatory mediator, excites and sensitizes nociceptor
neurons/fibers, thus evoking pain and hyperalgesia. The cellular signaling mechanisms
underlying these actions have remained unsolved, especially in regard to the identity of
channels that mediate acute excitation. Here, to clarify the contribution of transient receptor
potential vanilloid 1 (TRPV1), a heat-sensitive ion channel, to the BK-evoked nociceptor
excitation and pain, we examined the behavioral and physiological BK-responses in TRPV1 …
neurons/fibers, thus evoking pain and hyperalgesia. The cellular signaling mechanisms
underlying these actions have remained unsolved, especially in regard to the identity of
channels that mediate acute excitation. Here, to clarify the contribution of transient receptor
potential vanilloid 1 (TRPV1), a heat-sensitive ion channel, to the BK-evoked nociceptor
excitation and pain, we examined the behavioral and physiological BK-responses in TRPV1 …