[HTML][HTML] Members of RTP and REEP gene families influence functional bitter taste receptor expression
M Behrens, J Bartelt, C Reichling, M Winnig… - Journal of biological …, 2006 - ASBMB
Functional characterization of chemosensory receptors is usually achieved by heterologous
expression in mammalian cell lines. However, many chemoreceptor genes, including bitter
taste receptors (TAS2Rs), show only marginal cell surface expression. Usually, these
problems are circumvented by using chimeric receptors consisting of" export tags" and the
receptor sequence itself. It seems likely that chemoreceptor cells express factors for cell
surface targeting of native receptor molecules in vivo. For TAS2Rs, however, such factors …
expression in mammalian cell lines. However, many chemoreceptor genes, including bitter
taste receptors (TAS2Rs), show only marginal cell surface expression. Usually, these
problems are circumvented by using chimeric receptors consisting of" export tags" and the
receptor sequence itself. It seems likely that chemoreceptor cells express factors for cell
surface targeting of native receptor molecules in vivo. For TAS2Rs, however, such factors …