[HTML][HTML] Phosphorylation-dependent cellular localization and thermoprotective role of heat shock protein 25 in hippocampal progenitor cells
D Geum, GH Son, K Kim - Journal of Biological Chemistry, 2002 - ASBMB
The present study examined phosphorylation-dependent cellular localization and the
thermoprotective role of heat shock protein (HSP) 25 in hippocampal HiB5 cells. HSP25 was
induced and phosphorylated by heat shock (at 43° C for 3 h). HSP25, which was located in
the cytoplasm in the normal condition, translocated into the nucleus after the heat shock.
Transfection experiments with hsp27 mutants in which specific serine phosphorylation
residues (Ser 78 and Ser 82) were substituted with alanines or aspartic acids showed that …
thermoprotective role of heat shock protein (HSP) 25 in hippocampal HiB5 cells. HSP25 was
induced and phosphorylated by heat shock (at 43° C for 3 h). HSP25, which was located in
the cytoplasm in the normal condition, translocated into the nucleus after the heat shock.
Transfection experiments with hsp27 mutants in which specific serine phosphorylation
residues (Ser 78 and Ser 82) were substituted with alanines or aspartic acids showed that …