[PDF][PDF] Antigen processing: HLA-DO–a hitchhiking inhibitor of HLA-DM
PE Jensen - Current biology, 1998 - cell.com
PE Jensen
Current biology, 1998•cell.comRecent studies have revealed that the conserved major histocompatibility complex class II
molecule, HLA-DO, inhibits the class II antigen-processing pathway. HLA-DO, expressed in
only a subset of antigen-presenting cells, binds HLA-DM and blocks HLA-DM-catalyzed
peptide loading of class II molecules.
molecule, HLA-DO, inhibits the class II antigen-processing pathway. HLA-DO, expressed in
only a subset of antigen-presenting cells, binds HLA-DM and blocks HLA-DM-catalyzed
peptide loading of class II molecules.
Abstract
Recent studies have revealed that the conserved major histocompatibility complex class II molecule, HLA-DO, inhibits the class II antigen-processing pathway. HLA-DO, expressed in only a subset of antigen-presenting cells, binds HLA-DM and blocks HLA-DM-catalyzed peptide loading of class II molecules.
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