Primary immunodeficiency diseases: an update from the international union of immunological societies primary immunodeficiency diseases classification committee
RS Geha, LD Notarangelo, JL Casanova… - Journal of Allergy and …, 2007 - Elsevier
Primary immunodeficiency diseases (PIDs) are a genetically heterogeneous group of
disorders that affect distinct components of the innate and adaptive immune system, such as
neutrophils, macrophages, dendritic cells, complement proteins, natural killer cells, and T
and B lymphocytes. The study of these diseases has provided essential insights into the
functioning of the immune system. More than 120 distinct genes have been identified, whose
abnormalities account for more than 150 different forms of PID. The complexity of the …
disorders that affect distinct components of the innate and adaptive immune system, such as
neutrophils, macrophages, dendritic cells, complement proteins, natural killer cells, and T
and B lymphocytes. The study of these diseases has provided essential insights into the
functioning of the immune system. More than 120 distinct genes have been identified, whose
abnormalities account for more than 150 different forms of PID. The complexity of the …