CD81 regulates neuron-induced astrocyte cell-cycle exit
S Kelić, S Levy, C Suarez, DE Weinstein - Molecular and cellular …, 2001 - Elsevier
Astrocytes respond to contact with neurons by cell-cycle arrest and complex process
formation. In our effort to discover the molecular mechanisms that underlie this phenomenon
we have identified a known tetraspanin, CD81, as a critical component of astrocyte
responses to neuronal differentiation signals. Here we show that CD81 is expressed on the
surface of the astrocyte and that its expression level can be modulated by contact with
neurons. Further, using three separate antibodies, 2F7, Eat1, and Eat2, which recognize …
formation. In our effort to discover the molecular mechanisms that underlie this phenomenon
we have identified a known tetraspanin, CD81, as a critical component of astrocyte
responses to neuronal differentiation signals. Here we show that CD81 is expressed on the
surface of the astrocyte and that its expression level can be modulated by contact with
neurons. Further, using three separate antibodies, 2F7, Eat1, and Eat2, which recognize …