Proteins are modified and folded within the endoplasmic reticulum (ER). When the influx of
proteins exceeds the capacity of the ER to handle the load, the ER is “stressed” and protein
biogenesis is affected. We have previously shown that the induction of ER stress by ATP
depletion in podocytes leads to mislocalization of nephrin and subsequent injury of
podocytes. The aim of the present study was to determine whether ER stress is associated
with proteinuria in vivo and whether the immunosuppressant mizoribine may exert its …