Vitamin C intake and the risk of preterm delivery

AM Siega-Riz, JHE Promislow, DA Savitz… - American journal of …, 2003 - Elsevier
OBJECTIVE: Ascorbic acid deficiency may lead to premature rupture of the membranes.
STUDY DESIGN: The study included a prospective cohort of pregnant women, aged≥ 16
years, with singleton gestations who received care at one of four prenatal clinics in central
North Carolina from 1995 through 1998. Vitamin C intake preconceptionally and during the
second trimester was examined for its association with preterm delivery and subsets of
preterm labor, premature rupture of the membranes, and medical induction in 2064 women …