Assessment of in vivo mitochondrial metabolism by magnetic resonance spectroscopy
DE Befroy, KF Petersen, DL Rothman… - Methods in enzymology, 2009 - Elsevier
Magnetic resonance spectroscopy (MRS), a companion technique to the more familiar MRI
scan, has emerged as a powerful technique for studying metabolism noninvasively in a
variety of tissues. In this article, we review two techniques that we have developed which
take advantage of the unique characteristics of 31 P and 13 C MRS to investigate two
distinct parameters of muscle mitochondrial metabolism; ATP production can be estimated
by using the 31 P saturation‐transfer technique, and oxidation via the TCA cycle can be …
scan, has emerged as a powerful technique for studying metabolism noninvasively in a
variety of tissues. In this article, we review two techniques that we have developed which
take advantage of the unique characteristics of 31 P and 13 C MRS to investigate two
distinct parameters of muscle mitochondrial metabolism; ATP production can be estimated
by using the 31 P saturation‐transfer technique, and oxidation via the TCA cycle can be …