[HTML][HTML] Overexpression of MEKK3 confers resistance to apoptosis through activation of NFκB
AK Samanta, HJ Huang, RC Bast, WSL Liao - Journal of Biological …, 2004 - ASBMB
Many cancers have constitutively activated NFκB, the elevation of which contributes to
cancer cell resistance to chemotherapeutic agent-induced apoptosis. Although mitogen-
activated protein kinase/extracellular-regulated kinase kinase kinase-3 (MEKK3) has been
shown to participate in the activation of NFκB, its relations to apoptosis and cancer are
unclear. In this study, we established cell model systems to examine whether stable
expression of MEKK3 could lead to increased NFκB activity and confer resistance to …
cancer cell resistance to chemotherapeutic agent-induced apoptosis. Although mitogen-
activated protein kinase/extracellular-regulated kinase kinase kinase-3 (MEKK3) has been
shown to participate in the activation of NFκB, its relations to apoptosis and cancer are
unclear. In this study, we established cell model systems to examine whether stable
expression of MEKK3 could lead to increased NFκB activity and confer resistance to …