Response to smallpox vaccine in persons immunized in the distant past
SE Frey, FK Newman, L Yan, RB Belshe - Jama, 2003 - jamanetwork.com
ContextThere is renewed interest in use of smallpox vaccine due to the potential for a
bioterrorist attack. This would involve vaccinating health care workers who were previously
vaccinated. ObjectiveTo evaluate the use of diluted vaccinia virus in vaccination of
previously vaccinated (non-naive) participants. Design, Setting, and ParticipantsEighty non-
naive participants, aged 32 to 60 years, were randomized in a single-blinded study to
receive either undiluted or diluted (1: 3.2, 1: 10, or 1: 32) doses of smallpox vaccine. A …
bioterrorist attack. This would involve vaccinating health care workers who were previously
vaccinated. ObjectiveTo evaluate the use of diluted vaccinia virus in vaccination of
previously vaccinated (non-naive) participants. Design, Setting, and ParticipantsEighty non-
naive participants, aged 32 to 60 years, were randomized in a single-blinded study to
receive either undiluted or diluted (1: 3.2, 1: 10, or 1: 32) doses of smallpox vaccine. A …