[HTML][HTML] G-CSF–primed hematopoietic stem cells or G-CSF per se accelerate recovery and improve survival after liver injury, predominantly by promoting endogenous …

E Yannaki, E Athanasiou, A Xagorari… - Experimental …, 2005 - Elsevier
OBJECTIVE: On the basis of the recently recognized potential of bone marrow (BM) cells to
give rise to hepatocytes, we investigated the possibility that granulocyte colony-stimulating
factor (G-CSF)–mobilized BM cells could home to the injured liver and promote tissue repair.
We also examined the origin of cells (endogenous or BM) reconstituting liver after damage.
METHODS: Acute and chronic liver injury models were generated by injecting CCl4 in
C57Bl6 mice and G-CSF was administered in hematopoietic stem cell (HSC) mobilization …