Monocytes are established circulating precursors for tissue macrophages and dendritic cells
(DCs). Monocyte-derived macrophages and DCs fulfill critical roles in innate and adaptive
immunity during inflammation, and it is believed that monocytes also maintain these
populations in peripheral tissues during homeostasis. However, the continuous
replenishment of any DC pool by blood monocytes in the steady state remains to be
established, and some macrophage populations may be self-renewing in the steady state …