[HTML][HTML] Specificity of the tumor necrosis factor-induced protein 6-mediated heavy chain transfer from inter-α-trypsin inhibitor to hyaluronan: implications for the …
The formation of the hyaluronan-rich cumulus extracellular matrix is crucial for female fertility
and accompanied by a transesterification reaction in which the heavy chains (HCs) of inter-α-
trypsin inhibitor (IαI)-related proteins are covalently transferred to hyaluronan. Tumor
necrosis factor-induced protein-6 (TNFIP6) is essential for this transfer reaction. Female
mice deficient in TNFIP6 are infertile due to the lack of a correctly formed cumulus matrix. In
this report, we characterize the specificity of TNFIP6-mediated HC transfer from IαI to …
and accompanied by a transesterification reaction in which the heavy chains (HCs) of inter-α-
trypsin inhibitor (IαI)-related proteins are covalently transferred to hyaluronan. Tumor
necrosis factor-induced protein-6 (TNFIP6) is essential for this transfer reaction. Female
mice deficient in TNFIP6 are infertile due to the lack of a correctly formed cumulus matrix. In
this report, we characterize the specificity of TNFIP6-mediated HC transfer from IαI to …