[HTML][HTML] Defect in SHAP-hyaluronan complex causes severe female infertility: a study by inactivation of the bikunin gene in mice
L Zhuo, M Yoneda, M Zhao, W Yingsung… - Journal of Biological …, 2001 - ASBMB
Hyaluronan (HA) associates with proteins and proteoglycans to form the extracellular HA-
rich matrices that significantly affect cellular behaviors. So far, only the heavy chains of the
plasma inter-α-trypsin inhibitor (ITI) family, designated as SHAPs (serum-derivedhyaluronan-
associated proteins), have been shown to bind covalently to HA. The physiological
significance of such a unique covalent complex has been unknown but is of great interest,
because HA and the ITI family are abundant in tissues and in plasma, respectively, and the …
rich matrices that significantly affect cellular behaviors. So far, only the heavy chains of the
plasma inter-α-trypsin inhibitor (ITI) family, designated as SHAPs (serum-derivedhyaluronan-
associated proteins), have been shown to bind covalently to HA. The physiological
significance of such a unique covalent complex has been unknown but is of great interest,
because HA and the ITI family are abundant in tissues and in plasma, respectively, and the …